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A practical application of the combined model would be to predict the concentration and exposure time required to cause toxicity via overwhelming GSH metabolism as a function of quinone metabolism

Witte AB, Anestl K, Jerremalm E, Ehrsson H, Arnr ES (2005) Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds

Guglielmetti S, Boyte M-E, Smith CL et al (2025) Commercial and regulatory frameworks for postbiotics: an industry-oriented scientific perspective for non-viable microbial ingredients conferring beneficial physiological effects

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doi: 10.1016/j.jece.2019.103261