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Even though DOX cannot cross the bloodbrain barrier (BBB), it can cause substantial neurotoxicity with neuronal and synaptic loss, prompting cognitive deficits in the brain [39, 42] In the current work, DOX-induced oxidative stress was proved by higher levels of NOX4 and MDA, accompanied by loss of antioxidant defense mechanisms shown as lower GSH and SOD activities

We typically start with vagus nerve exercises like deep breathing, gargling, humming and singing, mindfulness & relaxation techniques like meditation, yoga and HRV training and optimizing sleep & circadian rhythms by having a consistent bedtime, focussing on morning sunlight exposure and more

[PubMed: 23359434] 244

Fate, activity, and impact of ingested bacteria within the human gut microbiota

Gorczyca, W., Gong, J

The acellular fraction of BALF was obtained through double centrifugation, and the supernatant was used for further analysis