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This IGF-1 independence eliminates a key confounding variable, allowing clean investigation of lipolytic pathway activity in isolation

Intestinal microbiota metabolism of l -carnitine, a nutrient in red meat, promotes atherosclerosis | Nature Medicine

How This Works IGF-1 LR3 is a synthetic analog of human insulin-like growth factor-1 engineered with an N-terminal extension (13 amino acids) and a glutamic acid substitution at position 3, resulting in significantly reduced binding affinity to IGF binding proteins [1]