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Treatment plan recommendations will be tailored to address the symptoms or behaviors your child is exhibiting

M.PorciattiV.et al

Acknowledgements We would like to thank the Kyoto Integrated Science & Technology Bio-Analysis Center for allowing us to use their LC-MS/MS (3200 QTRAP) and Editage (www.editage.jp) for English language editing

doi: 10.1242/jeb.155465 95 RostamiRAghasiMRMohammadiANourooz-ZadehJ

NF-B signaling regulates the expression of numerous downstream effectors, including cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and adhesion molecules, thereby linking oxidative stress to inflammation and leukocyte recruitment (Cook et al

In addition to chemotherapy based on gemcitabine and/or nab-paclitaxel, targeted therapy that addresses KRAS mutation, particularly KRAS-G12D, represents another promising strategy [3]