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To study whether LC-induced p21 cip1 expression is associated with histone acetylation, the effect of LC on the acetylation of histone H3 associated with the p21 cip1 promoter gene was then examined by using ChIP

Discovery and development of MEDI7247, a novel pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2, for treating hematological cancers

Notably, despite the dramatic difference in d 3 -TMAO production from oral d 3 -l-carnitine in omnivores versus vegans/vegetarians, the difference observed in the first step of that gut microbiotamediated transformation, conversion of d 3 -l-carnitine to d 3 -BB, was not significant, and if anything showed a trend toward a lower conversion rate in the omnivores ( P = 0.051

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Nature 324 , 7376 (1986)

To measure the level of total carnitine, the obtained supernatant was mixed with 1 M KOH in an Eppendorf tube and kept at 37 C for 20 min for the degradation of acylcarnitines