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Phospholipid synthesis and remodeling in innate immunity PL synthesis and remodeling are mainly dependent on three interconnected enzyme pathways, including the Kennedy pathway (for PC, PE synthesis), the CDP-DAG (cytidine diphosphate-diacylglycerol) pathway (for PS, PI and CL synthesis) and the Lands cycle pathway (remodeling pathway, for the reversible removal and reattachment of fatty acids (FAs) to PLs) (Fig

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