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Depending on the level of severity and time of diagnosis, some people can have the disease under control, while others will eventually have kidney failure as the disease progresses

Draft Ontario Health Technology Advisory Committee recommendations and evidence-based reviews are posted for 21 days on the Health Quality Ontario website, giving individuals and organizations an opportunity to provide comments prior to publication

As noted in the Effective Dates section below, while this requirement will become effective January 1, 2026, we will delay enforcement to April 1, 2026

MOTS-c: the mitochondrial peptide for disc cell survival MOTS-c is a 16-amino-acid peptide encoded by the mitochondrial genome that has recently emerged as a promising candidate for intervertebral disc degeneration

Chen et al., 2020)