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Isoform B, which is shorter by 44 amino acids, is inactive, while Isoform X1, a longer form with 264 amino acids, is not found in some higher species (Parande et al., 2024)

To date, only one study has found an association between adherence to the PHD and a 47% lower risk of dying from respiratory diseases (HR = 0.53, 95% CI: 0.480.59) [78]

the oxidized form has already donated its electrons, so it is not effective as an antioxidant because the sulfur group which allows it to bind to metals is already bound to another oxidized glutathione molecule and is not available for use for detoxification

FGFR, Fibroblast growth factor receptor

Copper is one vitamin that should be obtained from meals rather than supplements because supplementary copper may quickly overload the body

doi: 10.1016/j.molcel.2020.11.024 64 LiuJKangRTangD