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63 Building on this approach, Pathway-Level Information Extractor (PLIER) further integrates biological priors, such as pathway and marker gene sets, to improve interpretability and separate biological variation from technical noise particularly valuable for aging muscle tissue, in which subtle transcriptomic shifts are challenging to resolve

3 , e000117 (2017)

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Damaged mitochondria are transported to the plasma membrane by KIF5B, where Myo19 anchors them to cortical actin before Drp1-driven fission occurs

Our aim was to evaluate the M-DIRECT performance 5 years after its implementation