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Statistical analysis Mean SEM was used to express all the data

However, the last step of AsA synthesis is linked with a mitochondrial-localized enzyme called l-GalL dehydrogenase (l-GalLDH, EC 1.3.2.3) (Wheeler et al., 2015)

Conversely, integrase strand transfer inhibitors (INSTIs) such as Dolutegravir and Raltegravir are generally considered to have the most favorable mitochondrial safety profile, with little evidence of direct mtDNA toxicity