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According to the American Journal of Medicine, approximately 107,000 individuals are hospitalized every year for NSAID-related GI complications, and at least 16,500 deaths occur

Furthermore, esculetin (10-20 mg/kg) inhibits the expression of TNF- and IL-6 in isoproterenol induced myocardial toxicity in rats by inhibiting the activation of the NF-B signaling pathway (97)

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