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Additionally, one study showed that nearly 50% of HE recurrence was related to either no adherence or inappropriate dosing [59]

Here, we found that potential high replicators were more prevalent in patients with the CC genotype for IFNL4 SNP rs12979860, favouring spontaneous clearance (Fig

4.1.2 Injectables and CNS-targeting nanotherapeutics for neurodegenerative disease 4.1.2.1 Injectable cytokine releasing hydrogels Injectable hydrogels formed from natural polymers can encapsulate and gradually release anti-inflammatory cytokines at CNS sites, creating a confined immunoregulatory niche