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Previous studies have demonstrated that HIF2 is the isoform associated with the regulation of iron metabolism in a non-cancer context and CRC

It has been proven feasible to treat heart disease by targeting ferroptosis modulators

In summary, although relatively few studies have explored PD treatment through oxidative stress modulation over the past 5 years, the established neuroprotective and mechanistic similarities justify further investigation

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Free radicals can damage renal tubular cells and disrupt the function of sodium transporters, leading to sodium retention and increased blood volume, which further elevates blood pressure [82]

Nuclear glutathione S-transferase pi prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA products