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however, several ancestry-specific signals were markedly attenuated when combining populations, likely reflecting heterogeneity in allele frequencies and LD patterns

Heme oxygenase-1 (HMOX1) is a key regulatory gene of ferroptosis in atherosclerosis (67)

It has been found that the activation of the Notch signaling pathway in the cigarette-induced model of COPD and the further polarization of macrophages shifted toward the M1 phenotype with increased levels of IL-6, TNF- and reactive oxygen species

Regulation of nutritional metabolism in transition dairy cows: Energy homeostasis and health in response to post-ruminal choline and methionine

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CNS central nervous system Receptor-mediated targeting may further be combined with non-specific drug delivery systems (like protein conjugates, PEGylation, nanoparticles, liposomes, and the like) to greatly improve the pharmacokinetic and bio distribution properties of the drugs, which will significantly redirect the drugs specifically to receptor-expressing cells, tissues and organs, including the ones protected by specific blood-tissue barriers like e.g., the CNS, the blood-brain barrier (BBB), the retina and the testes