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Using an ERE-luciferase mouse, a reporter mouse that allows monitoring of ER transcriptional activity in a spatiotemporal manner, it was demonstrated that estrogen signaling is locally activated in keratinocytes in vitro (with 1 nM E2) and in vivo (with 10 nM E2)

The skin brightening and lightening properties of Glutathione Therapy are thought to be primarily from stimulation of pheomelanin (lighter) pigment production rather than eumelanin (darker)

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doi: 10.1038/s41430-023-01358-9 73

10.1037/h0043788 174 MonvilleC.TorresE