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My gut has always been off and I never knew why until I turned paleo

It has been studied to protect the liver from toxic damage (alcohol, antibiotics, etc.)

This decreases plasma levels of the drug, but increases levels at the site of action in the liver

Furthermore, increased oxidative DNA damage, renal apoptosis, and organ dysfunction have been reported

van Staa TP, Geusens P, Bijlsma JW, Leufkens HG, Cooper C

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