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The Nrf2 dissociation from Keap1 blocks the E3 activity of the Keap1 complex, stabilizes Nrf2, and promotes its nuclear accumulation, which initiates anti-ROS gene expression and contributes to cell survival in the stress

The specific vulnerability of tumor cells leveraging the aberrant NADPH-synthesis pathways can be exploited to induce cell death under various cellular stresses

1b), respectively

doi: 10.3727/096504016X14734149559061 113 ZhangPWeiYWangLDebebBGYuanYZhangJet al

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While a healthy diet rich in sulfur and antioxidants supports your levels, many people find it difficult to maintain optimal glutathione solely through food, especially as they age