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Using one viral vector, the gene therapy will deliver the three proteins to the retinal ganglion cells, which help transmit light signals from the eye to the brain

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7 Limitations and challenges Most recent studies on ferroptosis in ophthalmology have focused on RPECs or RGCs, but studies on the ability of Mller cells, vascular endothelial cells, PRs, and even corneal endothelial cells to induce ferroptosis are lacking, and comprehensive single-cell maps are lacking, leaving unresolved questions like the variations in the susceptibility of various cell types to ferroptosis, which can be parallel or mutually causal with apoptosis, necrosis, and pyroptosis (414)

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Solutions: Rotate injection sites more frequently Use new needle every time Clean site thoroughly with alcohol Let alcohol dry before injecting If persistent, reduce dose or switch to oral Usually harmless: Minor reactions common Should resolve within hours to days Not dangerous unless signs of infection (warmth, spreading redness, fever) No results after 4 weeks Problem: Not seeing expected healing or improvements

Autophagy as a molecular target for cancer treatment