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Mood changes such as irritability or feeling low are also common, as well as tingling sensations in the hands and feet that signal nerve involvement

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Contrarily, a study with 8 GH-deficient subjects found that IGF-1 administration increased lipid oxidation (being this effect more potent when co-administered with GH), energy expenditure, and insulin resistance [108, 183]

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Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition

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Twelve years, several rounds of animal results, and the count of published human efficacy trials sits at zero

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