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2017;97(2):721-766 3 Wilding JPH, Batterham RL, Calanna S, et al

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Use separate injection sites and separate syringes

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Different forms of cobalamin exist with linkages of methyl, adenosyl or hydroxo groups to cobalt, resulting in methylcobalamin, adenosylcobalamin and hydroxocobalamin, respectively

Safety therapeutic relevance: Even well-tolerated compounds require strong efficacy signals to justify continued development