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This review discusses established and recent literature in this area and proposes the hypothesis that estrogen plays a pleiotropic role in skin aging and that targeting estrogen signaling and biosynthesis could promote skin repair in older adults

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ANTIOXIDANT DEFENSE SYSTEMS: OVERVIEW AND RESPONSE TO CHRONIC EXERCISE Later sections of this review will discuss the fact that contracting skeletal muscle fibers can produce ROS via a variety of different pathways (86, 165, 321, 325) and outline how ROS are implicated in the etiology of exercise-induced skeletal muscle fatigue (22, 34, 105, 183, 184, 232, 321, 399, 400)

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