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High extracellular ADO levels, by ligation of low affinity ADORA2B, can influence the antigen-presenting activity of DCs (79, 80) and activate normal infiltrating cells that block the anti-tumor immune response (such as Tregs, MDSCs, and TAMs) (81), leading to peripheral tolerance (Figure 2)

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Fragment 176-191 might also activate other cellular signaling mechanisms that indirectly boost fat burning

Following the experiment, the results reported a reduction in weight and excess fat