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Infection, autoimmune origin, local manifestation of a general fibromatosis and part of generalized arterial disease, have been suggested as probablee causes of PD.[710] A family history of PD in 2% of patients and an association with Dupuytren's palmar fibromatosis in 20%, which is a known inherited autosomal dominant disease, appear to suggest that patients may have an inherited predisposition to this disease.[8] In addition to a genetic element, an autoimmune component may be present, as evidenced by the finding of abnormal serologic tests in 785 men with PD[11] and the finding of elevated antielastin antibodies in the sera of men with the disease.[12] It has been hypothesized that susceptible men respond to mechanical stress or microvascular trauma with a genetically aberrant wound healing process that involves the expression of growth factors and cytokines

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Novel methods to enhance surgical sperm retrieval: a systematic review

doi:10.1038/s41598-019-56302-4 8

doi: 10.1016/j.intimp.2016.04.010 173 WangH.ZhangD.HanQ.ZhaoX.ZengX.XuY.et al

Nat Rev Mol Cell Biol 14, 133139, 10.1038/nrm3522 (2013)