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After completing consolidation with PML::RARA negativity by RT-PCR, maintenance with mercaptopurine 50 mg/m2/day, methotrexate 15 mg/m2/week, and ATRA 25 mg/m2/day for 15 days every three months was carried out for two years, adapting doses to hematologic levels and changes in transaminases

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However, treatment with vitamin supplements failed to prevent cognitive decline [74]

Polymeric NPs also help in stabilizing therapeutic agents and apart from prolonging their half-life, also protect them from internal and external degradation ( Table 2