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11 , 15 , 27 It is well known that seminal OS induces LPO of the sperm cell membrane, sperm DNA fragmentation (SDF) and, consequently, apoptosis

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Notably, pharmacological inhibition of the PI3K-AKT-mTOR pathway reverses Sunitinib- and Sorafenib-resistant phenotypes driven by aberrant AKT activation, underscoring that this pathway represents a potential therapeutic node to overcome drug resistance (267, 272)

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At low, physiological concentrations, ROS function as essential second messengers in a process known as redox signaling

Additionally, the observed incidence of antibody (including neutralizing antibody) positivity in an assay may be influenced by several factors including assay methodology, sample handling, timing of sample collection, concomitant medications, and underlying disease