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High-risk groups include older adults, vegans, individuals with pernicious anaemia, those with malabsorption conditions such as Crohn's disease or coeliac disease, people taking metformin or proton pump inhibitors long-term, and those with recent nitrous oxide exposure including recreational use

The mechanism involves angiogenesis (new blood vessel formation) and upregulation of growth factor receptors at the injury site

In a study on Bells Palsy, Dr

The most common adverse effect that DiStefano observed are dosing errors