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Using either a mast cell stabilizer or a medication to reduce prostaglandin E2 synthesis (e.g., a COX2 inhibitor) stopped the hypersensitivity in the animal model of IBS.[ref] In the Lifehacks section (below), youll find a more comprehensive list of substances that also trigger mast cell degranulation

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And then lastly, I also found this very interesting, is they show that McKenzie exercises or Williams flexion exercises, which are directional preference, didnt really have an impact on someones short and long-term pain

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