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Emerging evidence suggests that a cocktail approach, that is, incorporating not only senolytics and senomorphics but also other therapeutic modalities, such as antioxidants, immune modulators, or metabolic enhancers may have a compounded effect in promoting healthy aging.261 Future clinical trials should explore these combination strategies, testing them in diverse age-related diseases to understand the potential for synergy and minimizing possible negative interactions between therapies

469 Meanwhile, the NAMPT is also a target of FoxO transcription factors that control the NAD + signaling in the regulation of hepatic triglyceride homeostasis

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Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice