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AMPs-Based Cancer Gene Therapy In addition to targeting common and drug-resistant tumors, AMPs in combination with other drugs also have many applications in gene therapy

Studies have shown that in contrast to a normal liver, there is an upregulation of FZD3/6/7 and Wnt3/4/5a expression in 95% of HCC and 68% of the surrounding tumor tissues, along with downregulation of sFRP1/5, which accumulates progressively with tumor advancement and the severity of fibrosis in surrounding tissues (72)