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Dose titration, side effect management, and treatment review are part of responsible prescribing

Studies have found that high NNMT expression promotes the release of inflammatory factors in adipose tissue, and NNMTi can effectively alleviate adipose inflammation and improve the microenvironment by inhibiting NNMT

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Although CHKs did not show differential expression at 24 hours post-treatment, it is plausible that such changes may manifest at later timepoints subsequent to RRM2 downregulation