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Caveolin-1 ameliorates hepatic injury in non-alcoholic fatty liver disease by inhibiting ferroptosis via the NOX4/ROS/GPX4 pathway

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Gloves create a barrier against contamination sources.Clean and disinfect your workspace thoroughlyAllow peptide vial to reach room temperatureWash hands and don sterile glovesGather all necessary supplies within reachCheck expiration dates on all materials Calculating Required Solvent Volume Determine your target concentration before adding any liquid

Orthogonal validation of NMR fragment hit 27 Encouraged by the relatively high binding affinity of compound 27 compared to expectations for fragments, we synthesised a series of analogues to explore the effect of modifying both the sulfonic acid and the ethoxy substituents on binding affinity (Table 1)