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Western blot analysis illustrated that sulforaphane increased the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase (NQO1), the latter two of which are anti-oxidative enzymes

Arsenault, Benoit J., et al

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24 Antioxidant enzymes play a crucial role in neutralizing oxidative stress, and their diminished levels indicate an excessive production of reactive oxygen species (ROS)

There was little scientific interest in ergo until 2005, when pharmacology professor Dirk Grundemann discovered that all mammals make a genetically coded transporter that rapidly pulls ergo into the red blood cells