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Variants in JAK2, TYK2, STAT1, STAT3, STAT4 genes increase UC susceptibility [19], and JAK3 knockout mice develop severe combined immunodeficiency, affecting T and B cell development, resulting in IEC differentiation defects and impaired intestinal barrier function, thus increasing susceptibility to UC [131]

10.1016/j.bbrc.2021.02.055 50 TangX.LiX.ZhangD.HanW

The mechanism behind this is synergistic rather than additive

[DOI] [PMC free article] [PubMed] [Google Scholar] 271.Al-Zaher AA, Moreno R, Fajardo CA, Arias-Badia M, Farrera M, De Sostoa J, et al

Global Glutathione Market Outlook, By Product, Value (US$ Mn) and Volume (Tons), 2019 - 2032 5.1.1

Skin samples were fixed with 4% paraformaldehyde, embedded in paraffin, and sectioned for H&E, Masson, and immunohistochemical staining