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Description

In vascular endothelial cells, EGT diminishes the accumulation of ROS and nitric oxide, indicating a partial reduction in oxidative stress and macrophage activation

So, for our next example, consider a 37-year-old woman with rheumatoid arthritis

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Erastin inhibits system Xc to lower GSH, reverses the Warburg effect, and thus primes mitochondria to amplify copper-mediated cuproptosis, culminating in irreversible mitochondrial damage