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An enzyme called tyrosinase plays a key role in this process its like the factory manager that tells your melanocytes to make more melanin

Majumdar, A., Nirwane, A

The skin surface was washed with PBS to remove unbound dye, and the stained skin was excised and rapidly frozen in liquid nitrogen

The specificity of MeCbl to interact with Cys180 of GSDME, which is evolutionally conserved in zebrafish, mice, and humans, together with its capability in inhibiting GSDME-mediated pyroptotic cell death across these species, strongly support that MeCbl can either be directly repurposed as a drug, or serve as a leading compound to ignite future development of specific GSDME inhibitory drugs, to prevent GSDME-mediated pyroptosis

Fatemi SH, Stary JM, Earle JA, Araghi-Niknam M, Eagan E (2005)

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