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Bonifcio VDB, Pereira SA, Serpa J, Vicente JB (2021) Cysteine metabolic circuitries: druggable targets in cancer

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Mutations in UPSrelated genes, such as parkin and UCHL1 , compromise ubiquitin tagging or removal, hindering substrate recognition and clearance [169]

On the one hand, GSH functions as an antioxidant that prevents lipid peroxidation in ferroptosis

Furthermore, ribose-5-phosphate can also be derived from uridine (which in turn could be derived from salvage pathways and degradation of endogenous or exogenous RNA), and this has been shown to fuel glucose-restricted solid cancers 74

This behavior is consistent with the formation of a uniform, coherent molecular layer that bridges peaks and valleys across the nanosurface 82