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These carcinogenic metabolites are called oncotoxins (141)

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In addition to triggering ADCC, CD38 ligation can induce direct activation of NK cell cytotoxicity and, although it may lead to depletion of CD38 high NK cells, it retains the population of cytotoxic NK cells [32, 33]

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8, 9, 10 The perception that a breach in the mucosal barrier incites mucosal inflammation is supported by the physical location of the intestinal epithelium, interposed as it is between the luminal contents and the mucosal surface (Figure 1)