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Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease

Ronchi JA, Francisco A, Passos LA, Figueira TR, and Castilho RF

In the last years, several preclinical studies and clinical trials have been effectuated using different GSK-3 inhibitors, actually with few encouraging results

The distinct actions of Myo-Ins and Mdivi-1 indicate that the Myo-Insdependent potentiation of ATP-mediated Ca signalling does not primarily depend on mitochondrial fission inhibition, consistent with a mechanism acting at the level of PIP metabolism or IP-mediated signalling, rather than through changes in mitochondrial structure

Mechanism of Actions NAC has emerged as a prominent antioxidant compound in both experimental and clinical research settings

The regulatory effect of NRF2 on those genes was well documented through antioxidative response element binding in the promoter or enhancers of target genes