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43,44 In specific, MAPK (mitogen-activated protein kinase) signaling, JAK-STAT, and NF-B (nuclear factor kappa-B) pathway have been implicated in mediating the favorable effects of SPMs in cardiometabolic disorders, 45,46 whereas the anti-inflammatory effects of synthetic SPMs are in marked contrast to their low picograms per milliliter concentrations reported in humans

Furthermore, recent findings reveal that alterations in BBB and its transporters affect the entry of therapeutic drugs designed to treat neurodegenerative diseases (Carvey et al., 2009)