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The enzymatic nucleic acid molecule may be formed in a hammerhead, hairpin, a hepatitis virus, group I intron or RNaseP RNA (in association with an RNA guide sequence) or Neurospora VS RNA motif, for example

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doi: 10.1016/bs.aambs.2022.05.003 219 RahmanA.HossainS.ShefatT.ChowdhuryM

the peptide conjugate and/or peptide-containing conjugation partner comprises a proteolytic cleavage site