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All studies written in preclinical and clinical language that highlighted the anticancer molecular mechanisms, signaling pathways and action targets of bromelain were included

A healthy gut is crucial for a healthy gut lining and microbiota, which directly affects the proper function of histamine-producing mast cells in the gut

Beyond classical applications in neurodegeneration, neuroinflammation, and tumor biology, HMC3-based platforms are increasingly relevant to studies of systemic and organ-brain interactions, including the gutbrain axis (351353), metabolic disorders (241), immune-endocrine cross-talk, and reproductive system pathologies (250), where microglia contribute to neuroendocrine regulation and reproductive axis remodeling

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