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found that the downregulation of CD44 led to a decrease in -catenin expression, thereby inducing leukemia cell cycle to arrest in the G0/G1 phase, where gene transcription is blocked, and cell proliferation is inhibited (101)

10.1002/glia.22679 103 KatoH.KurosakiR.OkiC.ArakiT

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ROS, which include superoxide, nitric oxide, hydroxyl radical, hydrogen peroxide, and peroxynitrite, can be generated from various sources including the electron transport chain or activated immune cells