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Distinct transforming growth factor- (TGF-) receptor subsets as determinants of cellular responsiveness to three TGF- isoforms

Older patients become more sensitive to the dosage and they require frequent blood tests and readjustment of their dose

Also, it is now discovered that inflammation and the accompanying generation of free radicals of oxygen (ROS) can trigger tissue plasticity by reverting cells to pluripotency [ 10 ]

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These typically develop first in the feet and hands, presenting as a stocking and glove distal distribution, with the longest axons displaying abnormalities first before spreading proximally as the symptoms progress (Seretny et al., 2014)

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