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In the four neuroendocrine organoid lines analysed, we observed increased H3K36me2 levels across many genomic regions, typically as broad, diffusely distributed domains

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Furthermore, heterogeneity in diagnostic criteria across studies makes it challenging to compare outcomes consistently

The safety profile was acceptable, with gastrointestinal side effects being the most common, consistent with amylin analogues

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Funding This work was supported by the Purdue Institute for Integrative Neuroscience