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In detail, over six decades of research have progressively deepened our understanding of the role of LAN and circadian disruption in BC development

Although DFO shows preclinical efficacy, its clinical translation remains limited, necessitating further evaluation of safety and effectiveness in stroke patients

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For example, when cardiomyocytes were incubated with the taurine transporter antagonist (guanidinoethane sulfonate-GES) or taurine transporter inhibitor (-alanine), mitochondrial oxidative stress increased and was accompanied by an accumulation of superoxide anions (O2), glutathione oxidation (GSSG), and inactivation of anti-oxidant enzymes such as aconitase (46,50)

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