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Clin Chem 55, 445-53 (2009)

The prediction of subcellular localization was performed by compiling results obtained from various softwares as Predotar, TargetP, and Wolfpsort

From June 2 to June 23th, 2021, the systemic chemotherapy combined with immunotherapy was given to this patient, more specifically: nab-paclitaxel 200mg d1, 8+ Seggio Capsules 60mg bid d1-14, sintilimab 200mg d1/3w were injected for this combined treatment

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Eryptosis, MCV and MCHC experiments were performed in Germany (Tbingen), glutathione measurements in Italy (Siena) and the measurements for enzymatic activities in Czech Republic (Olomouc)

Mechanistically, the activated MLKL can be localized in mitochondria, which may promote the formation of mitochondrial pores and the efflux of mtDNA into the cytoplasm, thereby promoting the activation of the cGAS-STING pathway in tumor cells after RT [282]