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This review would not have been possible without the support of Tom Smith, Vice President of Winegrowing at E & J Gallo Winery, and Nick Dokoozlian, Vice President of Viticulture, Chemistry, and Enology at E & J Gallo Winery

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Loss of IL-1 K133 ubiquitylation increases bioactive IL-1 levels in vivo To address whether Il1b K133R/K133R mice phenocopy in vitro responses and display elevated IL-1 due to an increased stabilization of IL-1, we intra-peritoneally injected WT control and Il1b K133R/K133R mice with LPS (100 g)

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