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The conceptual basis of 5-FU has been used to develop a thymidine analog, trifluorothymidine (TFT), as discussed below

In turn, increased A inhibits the proteasome functionality (353)

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Further studies linked the susceptibility to viral-induced myocarditis with a deficiency of GPx1, as GPx1 knockout (GPx1 / ) mice on a normal selenium diet were susceptible to viral-mediated myocarditis whereas wildtype (GPx1 +/+ ) mice were protected from viral-induced cardiac damage [28]

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In addition, these investigations predominantly focused on the GBM subtype of brain cancer, thereby restricting the extrapolation of their findings to other histological subtypes