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Animal handling and experimentation were carried out in accordance with the guidelines of the Guide for the Care and Use of Laboratory Animals and were approved by the Laboratory Animal Care and Use Committee of the Shaanxi University of Chinese Medicine

Tissue isolation As previously described by us [4, 6], at 6 h after injection of LPS, six mice in each group were decapitated

doi:10.1164/rccm.201003-0442OC Santus P, Corsico A, Solidoro P, Braido F, Di Marco F, Scichilone N (2014) Oxidative stress and respiratory system: pharmacological and clinical reappraisal of N-Acetylcysteine