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Nrf2, the master regulator of antioxidant response, showed approximately 70% decreased expression and activity in CF cells compared to normal controls (Chen et al., 2008)

10.1016/j.resp.2011.05.010 103 QuanH

A recent CDC study (Smith et al 2011) carried out a genome-wide mapping of gene SNPs and gene expression in 40 CFS patients and 40 controls

Pathogenic tau-induced oxidative stress and the disruption of lamin-rich nucleoskeleton activates silenced genes, leading to cell-cycle activation in neurons and triggering apoptotic cell death (Tay et al., 2020)

The upper result, plus the evidence that the ratio of IL18R1/CXCR3 is six fold more in the ovary than in the tumor, supports that IL18R1 is surplus and CXCL10 can directly bind to IL18R1 (Supplementary Fig